interferon treatment!

interferon treatment

Comprehensive Analysis

1) "Interferon" -- As to interferon treatment in·ter·fer·on Pronunciation: "in-t&(r)-'fir-"än Function: noun Etymology: interfere + 2-on : any of a group of heat-stable soluble basic antiviral glycoprotein cytokines of low molecular weight that are produced by cells exposed usually to the action of a virus, sometimes to the action of another intracellular parasite (as a bacterium), or experimentally to the action of some chemicals Pronunciation Symbols Interferons (IFNs) are natural proteins produced by the cells of the immune system of most vertebrates in response to challenges by foreign agents such as viruses, bacteria, parasites and tumor cells. Interferons belong to the large class of glycoproteins known as cytokines. Interferons assist the immune response by inhibiting viral replication within other cells of the body. 1 History 2 Types of interferon 3 The signaling pathway of interferons 4 Sources and functions of interferons 5 Viral induction of interferons 6 Pharmaceutical uses 7 See also 8 References 9 Further reading Whilst aiming to develop an improved vaccine for smallpox, two Japanese virologists, Yasu-ichi Nagano and Yasuhiko Kojima working at the then Institute for Infection Disease at the University of Tokyo, noticed that rabbit-skin or testis previously inoculated with UV-inactivated virus exhibited inhibition of viral growth when re-infected at the same site with live virus. They hypothesised that this was due to some “facteur inhibiteurâ€� (inhibitory factor), and began to characterise it by fractionation of the UV-irradiated viral homogenates using an ultracentrifuge. They published these findings in 1954 in the French journal now known as “Journal de la Société de Biologieâ€�.[1] While this paper demonstrated that the activity could be separated from the virus particles, it could not reconcile the antiviral activity demonstrated in the rabbit skin experiments, with the observation that the same supernatant led to the production of antiviral antibodies in mice. A further paper in 1958, involving triple-ultracentrifugation of the homogenate demonstrated that the inhibitory factor was distinct from the virus particles, leading to trace contamination being ascribed to the 1954 observations. 2) "Treatment" -- As to interferon treatment treat·ment Pronunciation: 'trEt-m&nt Function: noun 1 a : the act or manner or an instance of treating someone or something : HANDLING, USAGE <the star requires careful treatment> b : the techniques or actions customarily applied in a specified situation 2 a : a substance or technique used in treating b : an experimental condition Pronunciation Symbols Treatment may refer to: In health: Therapy, the act of remediation of a health problem In the arts: Film treatment, a prose telling of a story intended to be turned into a screenplay In science: In ecology, a subset of an experimental design where variables are manipulated by the experimenter Water treatment Sewage treatment Surface finishing, a number of industrial processes that can be applied to improve the surface of a manufactured item In apparel: In clothing, a process of modifying fabrics or clothing Treatment may also refer to: National treatment ..." 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